Erik at the ProductWiki Blog writes "Don't settle for Google Adsense":
There has been a lot of talk lately about the performance of Google AdSense as a viable source of revenue for bloggers and publishers alike. Recently, a post on TechCrunch inspired a debate about the potential performance of Google AdSense on the MySpace behemoth as Fox and Google have struck a billion dollar deal. While I believe that AdSense is a great source of potential revenue, it is by no means perfect and, in my opinion, needs to be updated to meet the demands of its users.
We are in an interesting position at ProductWiki as we generate our revenue from two different sources of pay-per-click (PPC) advertising: Google AdSense and Shopping.com Merchant Listings. These ads show up on all of our product pages (never at the same time) and each type of ad gets approximately a 50% share of our page views across a broad spectrum of products.
I've compiled data contrasting the performance of Shopping.com and Google AdSense on ProductWiki taken from a one week period at the end of last month.
Shopping.com AdSense Clickthrough rate (%) 29% 6.5% Revenue per click ($/click) $0.21 $0.19 eCPM ($/1000 impressions) $59 $13
Taking a look at the most significant of these figures (eCPM), Shopping.com outperforms AdSense by a factor of 4.6!

